, (5): número especial sobre aromaticidad y deslocalización. . teoría de la resonancia resulta muy útil ya que permite representar sistemas. Shimoda . Download IV Aromaticidad de heterociclos aromáticos nitrogenados Usando la teoría de resonancia y la teoría de enlace de valencia, se ha mostrado.
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I would like to deliver my great gratitude to Professors Magnus Rueping and Alan Spivey for the internships. Great thanks to Julie, Freddie and Bella Plant for having me in London during my research stay and in addition, I would like to thank to Papadopoulos Family for having me in Frankfurt during my research stay resonanciq their unconditional support during the last 7 years.
Approximation to the synthesis of Tashiromine Introduction Ammonium cerium IV nitrate. Distorsionless enhancement by polarization transfer.
High Resonance Mass Spectroscopy. Heteronuclear multiple bond conectivity. Heteronuclear multiple quantum coherence. High resolution mass spectroscopy. Rotating frame NOE spectroscopy. Atomic mass unit amu. Optical rotations at 20 C and 26 C. Asymmetric resonahcia of natural products,John Wiley and Sons. Total synthesis of natural products: Sus principales ventajas son: Stereoselective synthesis,Workbench ed.
Methods of organic chemistry Stuttgart; New York: Aldrichimica Acta,15, b Armstrong, A. The Nobel Prize in ChemistryAngew. Nature, b Dalko, P. Organometallics15, d Alper, H. resonandia
Tetrahedron58, c List, B. Synlettd Dalko, P. Perkin Trans 1,b Kozikowski, B. Asymmetry19, a Agami, C. Tetrahedron,44, c Uyehara, T.
Tetrahedron,46, e Uyehara, T. Asymmetry,2, b Davies, S. Synlett,9, d Abraham, E.
Asymmetry,5, b Davies, S. Thesis, Oxford, Davies, S. Tetrahedron,46, Ireland, R. En Davis et al. Acta15, Total synthesis of Natural products: The Chiron approach ; Pergamon Press: New York, ; Chapter Davis, F. Enolato de litio del metil acetato LDA, aromaticifad acetato ,- 78 C. Perkin Trans 1. Recientemente, Davies et al. Synlett,b Davies, S. Recientemente Davies et al. Tetrahedron67, Davies, S. Lett, dee, 2, and references cited therein.
Asymmetry21, and references cited therein. Tetrahedron Letters,53. Tetrahedron Letters,25, b Liebeskind, L.
Tetrahedron42, Takita, T. New York, b Juaristi, E. Acta redonancia, 27, c Podlech, J. Nature, Price, J. Asymmetry16, b Soengas, R.
Aromaticidade – Wikipedia, a enciclopedia libre
Asymmetry,12, Sathe, M. Molecules13, a Wust, P. Asymmetry11, b Roy, O. Tetrahedron59, c Nicolaou, K. Asymmetry21, a Porter, E. Nature, Tetrahedron Letters,49, Kazi, B.
Tetrahedron Letters,51. Chemistry and Pharmacology ; Cordell, G. San Diego, ; Vol. Chemistry and Pharmacology ; Brossi, A. New York, ; Vol.
Chemical and Biological Perspectives ; Pelletier, S. Synthesisb Huber, A. SynthesisCoyle, J. Salamanca, b Garrido, N. Asymmetry10, Urones, J. Asymmetry8, Urones, J. Asymmetry17, b Davies, S. Tetrahedron,48, Schultz, A. Tesis Doctoral, Salamanca, Garrido, N. Taking into account the progress that has been made in the study of the reactivity of cyclooctadienecarboxylates and its different applications in asymmetric synthesis through application of the Michael addition of chiral lithium amides methodology, in this work we want to carry on with the contribution to these different fields that have been studied and have been of interest in the research group: Approximation to the synthesis of Tashiromine.
Study of the reactivity of 1E,3Z -tert-butyl 5-oxocycloocta-1,3-dienecarboxylate, as a key adduct in the synthesis of Anatoxin-a. Approximation to the synthesis of Anatoxin-a. XO OX In search of a key adduct to the development of the synthetic route of Anatoxin-a, we get to the optimization of 5-oxo functionalized adduct, which required a detailed study and whose reactivity occupies a considerable part of this research work and the derivatives synthesized from this one can be possible precursors for the production of different types of alkaloids.
Synthesis of starting materials: Study of the Michael addition reactions of chiral lithium amides to cyclooctane carboxylates mono- and di-unsaturated systems.
Study of the reactivity of 1E,3Z tert-butyl 5-oxo-cycloocta-1,3-dienecarboxylate: Reactivity of tert-butyl and methyl 5,5-ethylenedioxycycloocta-1,7-dienecarboxylate in the approximation to the synthesis of Anatoxin-a. Study of the reactivity and stereochemistry of the obtained adducts by: Mechanistic interpretation of the achieved products. Reactions of Cycloocta-1,5-diene and cyclooctene: Preparation of di-unsaturated esters: The synthesis of intermediates 6 and 7 were achieved using cycloocta-1,5-diene as starting material, which is commercially available, following route A Scheme Treatment of cycloocta-1,5-diene with MCPBA for 90 min provided by vacuum fractional microdistillation: O O 50mL The studies of Utimoto, showed the effect of the catalyst in the regio and stereoselective opening of oxiranes using cyanotrimethylsilane and depending on the reaction conditions, it could be obtained isonitriles or nitriles due to the ambident character of the reagent, as it can be observed in Scheme Imi, K.
It was observed that in the reaction where Et 2 AlCl was used as catalyst, this one was quantitative and regioselective affording compound 3 which presents the two substituents in transdisposition as it showed the geminal proton-proton coupling 7. It has been studied different methods to esterify the mixture of the acids 4 and 5 to optimize this step Scheme In all of them, it was obtained the unsaturated tert-butyl esters 6 and 7, respectively, as a 1: On the other hand, the addition of tert-butyl trichloroacetimidate in the presence of BF 3.
In these three procedures the obtained yields are similar and the starting material can be easy recovered by acid-base extraction. Molecules9, a Greene, T. Protective Groups in Organic Synthesis. Foundations of organic chemistry series a Armstrong, A. Tetrahedron Letters,29, b Baldwin, J.